0035. Mitochondrial uncoupling contributes to fever in sepsis
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چکیده
منابع مشابه
0035. Mitochondrial uncoupling contributes to fever in sepsis
Introduction The major sources of body heat production are muscle activity, chemical reactions involving ATP synthesis and usage, coupled (oxidative phosphorylation) and uncoupled (proton leak) mitochondrial respiration. The cause of fever associated with sepsis has not been elucidated, particularly in sedated, ventilated patients who neither perform much voluntary skeletal muscle activity nor ...
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Methods Multiphoton confocal microscopy images were recorded over 45 minutes in intact renal sections (taken from healthy rats) incubated in either physiologic saline solution (PSS) (n = 6), sham serum (n = 3), septic serum (n = 3), and septic serum co-incubated with 10nM of the anti-oxidant 4-OH-Tempo (n = 4). Pooled septic serum was obtained from (n = 5) rats 24 hrs after induction of faecal ...
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The aim of this review is to provide an overview of current knowledge on the three mammalian uncoupling proteins, UCP-1, UCP-2, and UCP-3. Heart Metab. 2010;48:32–34.
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Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we examined alterations of cardiac sphingolipid metabolism in a mouse with streptozotocin-induced type 1 diabetes. Diabetes increased expression of desa...
متن کاملMitochondrial function in sepsis.
BACKGROUND The relevance of mitochondrial dysfunction as to pathogenesis of multiple organ dysfunction and failure in sepsis is controversial. This focused review evaluates the evidence for impaired mitochondrial function in sepsis. DESIGN Review of original studies in experimental sepsis animal models and clinical studies on mitochondrial function in sepsis. In vitro studies solely on cells ...
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ژورنال
عنوان ژورنال: Intensive Care Medicine Experimental
سال: 2014
ISSN: 2197-425X
DOI: 10.1186/2197-425x-2-s1-o8